
The Amyloid Trap

Asking „WHY?“
The 3 subtypes of Alzheimers
Treating Alzheimers
Level 1 : The common ground
Level 2 : The Individualization
Biochemical Rationale of Alzheimer Treatment
Cutting up APP

The 52 contributing factors to ß-cleavage and thereby Amyloid formation and Alzheimers
- Reduce caspase-6 cleavage
- Reduce caspase-3 cleavage
- Increase neprilysin
- Increase Insulin-degrading enzyme (IDE)
- Increase microglial clearance of Aß
- Increase autophagy
- Increase brain derived neurotrophic factor (BDNF)
- Increase nerve growth factor (NGF)
- Increase netrin-1
- Increase activity-dependent neuroprotective protein (ADNP)
- Increase vasoactive intestinal peptide (VIP)
- Reduce Homocysteine
- Increase protein phosphatase 2A (PP2A) activity
- Reduce phospho-tau
- Increase phagocytosis index
- Increase Insulin Sensitivity
- Enhance leptin sensitivity
- Improve axoplasmic transport
- Enhance mitochondrial function and biogenesis
- Reduce oxidative damage and optimise reactive oxygen species (ROS) production
- Enhance cholinergic neurotransmission
- Increase cholinergic neurotransmission
- Increase synaptoblastic signalling
- Reduce synaptoclastic signalling
- Improve long-term potentiation (LTP)
- Optimize estradiol
- Optimize progesterone
- Optimize E2:P (estradiol to progresterone ratio)
- Optimize free T3
- Optimize free T4
- Optimize thyriod-stimulating hormone (TSH)
- Optimize pregnenolone
- Optimize testosterone
- Optimize cortisol
- Optimize dehydroepiandrosterone (DHEA)
- Optimize Insulin secretion and signalling
- Activate peroxisome proliferator-activated receptor gamma (PPAR-y)
- Reduce inflammation
- Increase resolvins
- Enhance detoxification
- Improve vascularization
- Increase cyclic adenosine monophosphate (cAMP)
- Increase glutathione
- Provide synaptic components
- Optimize all metals
- Increase gamma-amino-butyric-acid (GABA)
- Increase Vitamin D signalling
- Increase silent information regulator T1 (SirT1)
- Reduce nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB)
- Increase telomere length
- Reduce glial scarring
- Enhance stem-cell-mediated brain repair


Gerrit Keferstein is a Medical Doctor specialised in Performance & Functional Medicine. He is most known for his work on the optimisation of recovery and adaptation in elite athletes.