What we know about the human brain
What we know about schizophrenic disorders
Conventional Treatment Options
A Treatment Outlook
Getting to the root of inflammation
Digestive Function and the brain
Gut Bacteria and Psychiatric Disorders
Intestinal Permeability and the Brain
- A study on the diversity of the microbiome of the throat found that people with schizophrenia had 400 times the population of lactic acid bacteria than than their healthy counterparts. The same study found that some metabolic pathways for siderophores, glutamate, and vitamin B12 were also different in those with schizophrenia. They also found that the biodiversity of the microbiome was larger in the healthy controls.
- Another study also found that the organism Lactobacillus phage phiadh was significantly more abundant in patients with schizophrenia. This microorganism has been tied to diabetes, which is common in people with schizophrenia. It was also found that none of those taking the drug valproate (Depakote) had Lactobacillus phage phiadh in their pharynx when tested, compared to the 17 of 35 individuals not taking the drug.
- Some individuals with bipolar disorder and schizophrenia have consistent, low-grade inflammation associated with dysfunction in the gut microbiome.
- Crohn’s Disease is associated with the yeast Saccharomyces cerevisiae. One study found that some people with schizophrenia and bipolar disorder have elevated levels of antibodies for this organism, especially those with gastric distress.
- There is some evidence that some people with schizophrenia and bipolar disorder have sensitivities to lactose and gluten and that ingestion of these can lead to inflammation.
- One study found that those hospitalized with acute mania had more recent exposure to antibiotics, suggesting an increased rate of bacterial infections in comparison with healthy controls.
Intestinal Immune Activity
Gerrit Keferstein is a Medical Doctor specialised in Performance & Functional Medicine. He is most known for his work on the optimisation of recovery and adaptation in elite athletes.